Tipifarnib
|
Farnesyltransferase inhibitor
|
II
|
12
|
PTCL
|
50 % ORR
|
NCT00082888
|
[49]
|
Darinaparsin
|
Organic arsenic compound
|
II
|
7
|
PTCL
|
28.6 % ORR, 3.6 months median TTF, 6.4 months OS
|
NCT00421213
|
[50]
|
Panobinostat
|
Pan-deacetylase inhibitor
|
II
|
139
|
CTCL
|
17.3 % ORR
|
NCT00425555
|
[51]
|
Denileukin diftitox
|
Interleukin fusion protein
|
III
|
263
|
CTCL
|
38 % ORR, median DoR was 277 days
|
NCT00050999
|
[52]
|
NCT00051012
|
Ixazomib
|
Proteasome inhibitor
|
I
|
4
|
PTCL
|
1 PR
|
NCT00893464
|
[53]
|
Sorafenib
|
Multikinase inhibitor
|
—
|
12
|
PTCL/CTCL
|
42 % ORR, 4 CR, 1 PR
|
—
|
[54]
|
Forodesine
|
PNP inhibitor
|
II
|
101
|
CTCL
|
No CR, 11 % PR, 50 % SD, median DoR was 191 days
|
NCT00501735
|
[55]
|