Fig. 2

Significantly decreased CD3 and TCR α/β in peripheral blood cells but no significant change in CD95. Percent CD3 lymphocytes in EDTA whole-blood-derived lymphocytes of GBM patients (P) and controls (H) (a, left) and the corresponding CD3 expression densities (mean fluorescence intensity (MFI)) (a, middle) and absolute numbers of CD3-positive lymphocytes in patients (a, right). Normal ranges of absolute numbers are indicated as blue arrowheads on the y-axis (a, right). Percent TCRα/β lymphocytes in GBM patients and healthy controls (b, left) and the corresponding MFI distribution (b, middle) and absolute numbers of TCRα/β cells/μl blood (b, right). Percent CD95 lymphocytes in GBM patients as compared to controls (c, left) and the corresponding distribution of CD95 MFI (c, middle) and absolute CD95-expressing lymphocytes (c, right). IDH-1 mutated patients outside of the 25–75 boxed percentile are shown as red-filled circles. IDH-1 mutated patients outside of the 25–75 boxed percentile are shown as red-filled circles