From: Short telomere length and its correlation with gene mutations in myelodysplastic syndrome
 | Univariable | Multivariable | ||||
---|---|---|---|---|---|---|
Risk factors | HR | 95Â % CI | P | HR | 95Â % CI | P |
Revised IPSS | Â | Â | 0.010 | Â | Â | Â |
Very low vs. low | 2.242 | 0.275–18.287 | 0.451 |  |  |  |
Very low vs. intermediate | 1.577 | 0.184–13.552 | 0.678 |  |  |  |
Very low vs. high | 6.731 | 0.874–51.865 | 0.067 |  |  |  |
Very low vs. very high | 6.432 | 0.808–51.197 | 0.079 |  |  |  |
Complex CG vs. not | 2.915 | 1.229–6.918 | 0.015 |  |  |  |
del(7q)/−7 vs. normal (karyotype) | 4.483 | 1.951–10.302 | <0.001 |  |  |  |
FISH 5 abnormal vs. normal | 2.994 | 1.248–7.183 | 0.014 |  |  |  |
BM blast ≥10 vs. <10 % | 2.476 | 1.200–5.112 | 0.014 | 2.623 | 1.237–5.563 | 0.012 |
TP53 mutated vs. normal | 4.875 | 2.031–11.703 | <0.001 | 5.257 | 1.341–33.095 | 0.001 |
U2AF1 mutated vs. normal | 2.325 | 1.035–5.222 | 0.041 | 3.544 | 1.485–8.458 | 0.004 |
Percentage of cells with low TL compared to NC ≥80 vs. <80 % | 2.47 | 1.148–5.314 | 0.021 | 2.248 | 1.023 – 4.937 | 0.044 |