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Table 4 Univariable and multivariable Cox analysis of the overall survival of 58 MDS patients

From: Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

 

Univariable

Multivariable

Risk factors

HR

95 % CI

P

HR

95 % CI

P

Revised IPSS

  

0.010

   

Very low vs. low

2.242

0.275–18.287

0.451

   

Very low vs. intermediate

1.577

0.184–13.552

0.678

   

Very low vs. high

6.731

0.874–51.865

0.067

   

Very low vs. very high

6.432

0.808–51.197

0.079

   

Complex CG vs. not

2.915

1.229–6.918

0.015

   

del(7q)/−7 vs. normal (karyotype)

4.483

1.951–10.302

<0.001

   

FISH 5 abnormal vs. normal

2.994

1.248–7.183

0.014

   

BM blast ≥10 vs. <10 %

2.476

1.200–5.112

0.014

2.623

1.237–5.563

0.012

TP53 mutated vs. normal

4.875

2.031–11.703

<0.001

5.257

1.341–33.095

0.001

U2AF1 mutated vs. normal

2.325

1.035–5.222

0.041

3.544

1.485–8.458

0.004

Percentage of cells with low TL compared to NC ≥80 vs. <80 %

2.47

1.148–5.314

0.021

2.248

1.023 – 4.937

0.044