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Table 4 Univariable and multivariable Cox analysis of the overall survival of 58 MDS patients

From: Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

  Univariable Multivariable
Risk factors HR 95 % CI P HR 95 % CI P
Revised IPSS    0.010    
Very low vs. low 2.242 0.275–18.287 0.451    
Very low vs. intermediate 1.577 0.184–13.552 0.678    
Very low vs. high 6.731 0.874–51.865 0.067    
Very low vs. very high 6.432 0.808–51.197 0.079    
Complex CG vs. not 2.915 1.229–6.918 0.015    
del(7q)/−7 vs. normal (karyotype) 4.483 1.951–10.302 <0.001    
FISH 5 abnormal vs. normal 2.994 1.248–7.183 0.014    
BM blast ≥10 vs. <10 % 2.476 1.200–5.112 0.014 2.623 1.237–5.563 0.012
TP53 mutated vs. normal 4.875 2.031–11.703 <0.001 5.257 1.341–33.095 0.001
U2AF1 mutated vs. normal 2.325 1.035–5.222 0.041 3.544 1.485–8.458 0.004
Percentage of cells with low TL compared to NC ≥80 vs. <80 % 2.47 1.148–5.314 0.021 2.248 1.023 – 4.937 0.044