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Table 4 Causes of death according to donor HLA matching

From: The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party

 

HLA 10/10

HLA 9/10

HLA 8/10

Relapse

552 (47.5 %)

173 (43.4 %)

21 (36.2 %)

Infection

249 (21.3 %)

100 (25.1 %)

21 (36.2 %)

GVHD

202 (17.3 %)

80 (20.1 %)

10 (17.2 %)

Graft failure/rejection

11 (0.9 %)

1 (0.3 %)

0

Cardiac toxicity

8 (0.7 %)

4 (1 %)

1 (1.7 %)

Haemorhage

14 (1.2 %)

5 (1.3 %)

1 (1.7 %)

VOD

12 (1 %)

8 (2 %)

0

Idiopathic pneumonia

25 (2.1 %)

9 (2.3 %)

0

Second malignancy

24 (2.1 %)

5 (1.3 %)

0

Other SCT-related

70 (6 %)

14 (3.5 %)

4 (6.9 %)

  1. GVHD graft-versus-host disease, SCT stem cell transplantation, VOD veno-occlusive disease