Fig. 3
From: Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro
EPOR signaling in myeloma cells. a Knockdown of EPOR in INA-6 reduces p-ERK-1/2 and p-JAK-2 after rhEPO treatment (10 U/ml, 5 min). b Immunoblotting shows specific knockdown of EPOR in INA-6 cells using siRNA directed against EPOR mRNA. c Immunoblotting of four different primary myeloma cells after rhEPO treatment (10 U/ml, 5 min) shows an increase in both p-ERK1/2 and p-JAK-2 in the patient samples