Fig. 6

MYC is heterogeneously expressed and its expression is co-localized with active β-catenin in ALK + ALCL tumor cells. a Immunofluorescence assay was performed in 3 cases of primary tumors with MYC and active β-catenin double staining, and the results showed MYC is significantly (P < 0.0001) co-localized with active β-catenin in tumor cells (shown in the table). Ten random fields of the 3 cases were chosen under microscope, and one representative field (400×) was shown here. The correlation analysis was performed by Fisher’s exact test. b Two different fields of a case of ALK + ALCL primary tumor immunostained for MYC were shown. The above showed a focus with many lymphoma cells strongly positive for MYC (red arrows). A lymphoma cell that was only dimly positive for MYC was also noted (black arrow). Scattered reactive small lymphocytes and benign fibroblasts in the background were negative. Below showed another focus in which lymphoma cells strongly positive for MYC being not as frequent. A good number of lymphoma cells negative or weakly positive for MYC were noted (black arrow, immunohistochemistry, 400×)