Table 1 6/20 NLRs are localized in nucleus, suggesting assembly of a variety of nuclear inflammasomes. Several NLR proteins have potential to form nuclear inflammasome with caspase-1
Symbol | Source | Subcellular localizations (probabilities) | ||||
|---|---|---|---|---|---|---|
Database 1a | Database 2b | Summary | ||||
High | Middle | Low | ||||
NOD1 | 1 | PM | Cytosol | Nucleus | Cytoplasm | Cytoplasm |
NOD2 | 1 | Cytoskeleton | PM | Cytosol | Cytoplasm | Cytoplasm |
NOD3 | 1 | Cytoplasm | Cytoplasm | Cytoplasm | ||
NOD4 | 1 | Cytosol | Nucleus | Cytoskeleton | Cytoplasm | Cytoplasm |
NALP1 | 1 | Cytosol | Nucleus | Nucleus | Nucleus | |
NALP2 | 1 | Cytosol | Nucleus | Cytoplasm | ||
NALP3 | 1 | Cytosol | Extracellular | Nucleus | Nucleus | Nucleus |
NALP4 | 1 | Extracellular | Cytosol | Extracellular | ||
NALP5 | 1 | Nucleus | Mito | Cytosol | Nucleus | Nucleus |
NALP6 | 1 | Nucleus | PM | Cytosol | Nucleus | Nucleus |
NALP7 | 1 | Cytosol | Cytosol | |||
NALP9 | 1 | Cytoplasm | Cytoplasm | Cytoplasm | ||
NALP10 | 1 | PM | Nucleus | Cytosol | Cytoplasm | PM |
NALP12 | 1 | Cytosol | Cytoplasm | Cytosol | ||
NALP14 | 1 | Cytosol | Cytosol | |||
NAIP | 1 | Extracellular | PM | Nucleus | Extracellular | |
IPAF | 1 | Cytosol | Nucleus | Cytoskeleton | Cytosol | Cytosol |
IFI16 | 2 | Nucleus | Cytosol | Nucleus | Nucleus | |