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Table 3 6/27 caspase-1 nuclear substrates have transcription regulatory functions

From: Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Substrate

Location summary

Transcription factor

Inflammation

PAZAR TF (ID)

NCBI

Inflammatory function

PMID

HSPB3

Nucleus

    

HNRNPA2B1

Nucleus

  

Pro-inflammation

26030368

SMG7

Nucleus

  

Pro-inflammation

21467779

TFAP2A

Nucleus

TF0000385

a

Pro-inflammation

10504447

PTPN18

Nucleus

    

MCM3

Nucleus

  

Pro-inflammation

12421976

VPS72

Nucleus

    

EEF1A1

Nucleus

TF0000325

 

Pro-inflammation

22829547

LMNA

Nucleus

  

Pro-inflammation

18551513

GIT2

Nucleus

  

Pro-inflammation

16715100

PCBP2

Nucleus

  

Pro-inflammation

19740317

PARP1

Nucleus

  

Pro-inflammation

17430886

ATXN3

Nucleus

  

Pro-inflammation

11466410

U2AF2

Nucleus

    

HTATSF1

Nucleus

 

a

Pro-inflammation

21830069

BIRC4

Nucleus

    

MATR3

Nucleus

    

NAV3

Nucleus

    

ASCC2

Nucleus

    

SCAF11

Nucleus

    

TUB

Nucleus

 

a

  

ZC3HAV1

Nucleus

    

ZMAT2

Nucleus

    

PPARG

Nucleus

TF0000041

a

Pro-inflammation

11089900

NONO

Nucleus

    

MCM5

Nucleus

  

Anti-inflammation

10551502

TRIM28

Nucleus

TF0000281

a

Anti-inflammation

22995936

  1. Abbreviation: PAZAR TF Transcription factor database (http://www.pazar.info/cgi-bin/tf_search.cgi), NCBI National Center of Biotechnology Information, PMID PubMed identifier
  2. aGenes are confirmed in NCBI