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Table 1 The impact of HGF/c-MET pathway in different types of lymphoma

From: The role of HGF/c-MET signaling pathway in lymphoma

Type of lymphoma Outcome Cellular functions, mechanisms, and clinical consequence References
B cell-derived Unfavorable Enhanced metastasis in vivo [15]
DLBCL Favorable  ▪ Increase survival of patients
 ▪ c-MET retained the physiologic growth control
 ▪ c-MET(+) DLBCL was more proliferated and more responsive to therapy
 ▪ c-MET directly binds to the pro-apoptotic protein FAS
[18, 23]
Primary intestinal DLBCL Unfavorable Reduce survival of patients [19]
DLBCL Unfavorable  ▪ Increase the activities of MEK-MAPK
 ▪ Increase the activities of PI3K-PKB/AKT and its substrates GSK3 and FOXO3a
 ▪ Inhibition of fatty acid synthase
[27, 28, 33]
PEL Unfavorable Required for tumor progression in xenograft model [37]
BL Unfavorable  ▪ Protection of cells from apoptosis
 ▪ Activation of MAPK
 ▪ Induce drug resistance of tumor cells
[39, 40, 64]
MALT Unfavorable Required for tumor cell proliferation/growth [41]
cHL Favorable Increase survival of patients [42, 43]
cHL Unfavorable Increase the relapse [47]
ALCL Unfavorable Required for tumor progression [48]
NKTCL Unfavorable Required for tumor cell proliferation [49]
TLL Unfavorable Required for tumor progression [52, 53, 65]