The role of HGF/c-MET signaling pathway in lymphoma

Table 1 The impact of HGF/c-MET pathway in different types of lymphoma

Type of lymphoma	Outcome	Cellular functions, mechanisms, and clinical consequence	References
B cell-derived	Unfavorable	Enhanced metastasis in vivo	[15]
DLBCL	Favorable	▪ Increase survival of patients ▪ c-MET retained the physiologic growth control ▪ c-MET(+) DLBCL was more proliferated and more responsive to therapy ▪ c-MET directly binds to the pro-apoptotic protein FAS	[18, 23]
Primary intestinal DLBCL	Unfavorable	Reduce survival of patients	[19]
DLBCL	Unfavorable	▪ Increase the activities of MEK-MAPK ▪ Increase the activities of PI3K-PKB/AKT and its substrates GSK3 and FOXO3a ▪ Inhibition of fatty acid synthase	[27, 28, 33]
PEL	Unfavorable	Required for tumor progression in xenograft model	[37]
BL	Unfavorable	▪ Protection of cells from apoptosis ▪ Activation of MAPK ▪ Induce drug resistance of tumor cells	[39, 40, 64]
MALT	Unfavorable	Required for tumor cell proliferation/growth	[41]
cHL	Favorable	Increase survival of patients	[42, 43]
cHL	Unfavorable	Increase the relapse	[47]
ALCL	Unfavorable	Required for tumor progression	[48]
NKTCL	Unfavorable	Required for tumor cell proliferation	[49]
TLL	Unfavorable	Required for tumor progression	[52, 53, 65]

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