Circular RNAs in cancer: an emerging key player

Table 1 Summary of circRNAs in cancer

Cancer name	CircRNA name	Expression level	Scope	Sample	Intersection molecules and/or pathway	References
Bladder carcinoma	circTCF25	Up	Bladder carcinoma vs normal	Tissues (n = 40)	miR-103a-3p,miR-107; circTCF25-miR-103a-3p/miR-107-CDK6	Zhong et al. [28]
cSCC	hsa_circ_0035381	Up	cSCC vs normal	Tissues (n = 12)	hsa-miR-124-5p,hsa-miR-9-5p	Sand et al. [32]
cSCC	hsa_circ_0022383	Down	cSCC vs normal	Tissues (n = 12)	hsa-miR-124-5p	Sand et al. [32]
ESCC	cir-ITCH	Down	ESCC vs normal	Tissues (n = 684)	miR-7, miR-17, and miR-214;Wnt/β-catenin pathway	Li et al. [34]
Gastric cancer	has_circ_002059	Down	Gastric cancer vs normal	Tissues (n = 101)	–	Li et al. [23]
Gastric cancer	has_circ_002059	Down	Gastric cancer vs normal	Plasma (n = 36)	–	Li et al. [23]
CRC	hsa_circ_001988	Down	CRC vs normal	Tissues (n = 31)	–	Wang et al. [24]
CRC	cir-ITCH	Down	CRC vs normal	Tissues (n = 45)	Wnt/β-catenin pathway	Huang et al. [25]
HCC	hsa_circ_0001649	Down	HCC vs normal	Tissues (n = 89)	–	Qin et al. [26]
LSCC	hsa_circ_104912	Down	LSCC vs normal	Tissues (n = 52)	–	Xuan et al. [27]
LSCC	hsa_circ_100855	Up	LSCC vs normal	Tissues (n = 52)	–	Xuan et al. [27]
APL	f-circRNA	–	f-circRNA-expressing vas normal	Cells	PI3K and MAPK signal transduction pathways	Guarnerio et al. [29]

Notes: Up upregulated, down downregulated
Abbreviations: circRNAs circular RNAs, cSCC cutaneous squamous cell carcinoma, ESCC esophageal squamous cell carcinoma, CRC colorectal cancer, HCC hepatocellular carcinoma, LSCC laryngeal squamous cell cancer, APL acute promyelocytic leukemia

ISSN: 1756-8722