Nuclear microRNAs in normal hemopoiesis and cancer

Table 1 Nuclear-localized miRNAs in normal hemopoiesis

Nuclear miRNA	Lineage/cell type	Function/activity	Significance	Reference
miR-223	Myeloid	Binds to the promoter region of NF1A to induce transcriptional silencing	Repression of NF1A to promote granulopoiesis	[42]
miR-706	Myeloid (Lin⁻Sca⁺Kit⁺ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20	Detained in the nucleus to derepress target mRNA (e.g. Stat1)	Increased expression of transcription factor (e.g. Stat1) to promote granulopoiesis	[43, 57]
miR-690	Myeloid (Lin⁻Sca⁺Kit⁺ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20	Unknown	Unknown	[43]
miR-709	Myeloid (Lin⁻Sca⁺Kit⁺ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20	Unknown	Unknown	[43]
miR-467a*	Lin⁻Sca⁺Kit⁺ hemopoietic stem/progenitor cells, MPRO, EL4, A20	Unknown	Unknown	[43]

ISSN: 1756-8722