Skip to main content

Table 1 Nuclear-localized miRNAs in normal hemopoiesis

From: Nuclear microRNAs in normal hemopoiesis and cancer

Nuclear miRNA Lineage/cell type Function/activity Significance Reference
miR-223 Myeloid Binds to the promoter region of NF1A to induce transcriptional silencing Repression of NF1A to promote granulopoiesis [42]
miR-706 Myeloid (LinSca+Kit+ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20 Detained in the nucleus to derepress target mRNA (e.g. Stat1) Increased expression of transcription factor (e.g. Stat1) to promote granulopoiesis [43, 57]
miR-690 Myeloid (LinSca+Kit+ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20 Unknown Unknown [43]
miR-709 Myeloid (LinSca+Kit+ hemopoietic stem/progenitor cells, promyelocytes, myelocytes and granulocytes), MPRO, EL4, MEL, A20 Unknown Unknown [43]
miR-467a* LinSca+Kit+ hemopoietic stem/progenitor cells, MPRO, EL4, A20 Unknown Unknown [43]