Fig. 2

Expression of tumor markers. a Expression of SDF1α levels after treatments and differences with tumor size. Analyses of linear regression performed in the sunitinib and bevacizumab treated tumors showed a significant correlation in these groups (r = 0.844, P = 0.0002). b Hemoglobin content in treated and control tumors analyzed according to tumor size. Analyses of linear regression performed in the sunitinib and bevacizumab treated tumors showed r = 0.69 and P = 0.016. c Western blotting determination of VEGF-A, HIF1α, and GCSF. d Growth curved derived from U87MG cell suspensions obtained from U87MG xenografts treated for 35 days with bevacizumab and scored as indicated in the text in high CXCR4 expression (cell suspensions from larger tumors) and low CXCR4 expression (cell suspensions from smaller tumors) and grown for 45 days with or without bevacizumab