Fig. 7
In vivo effects of CXCR4 antagonist, PRX177561, alone or in combination with bevacizumab or sunitinib in orthotopic intra-brain models: overall survival determinations. Luciferase-expressing U87 cells were injected in female nude mice as described, and 5 days after cell injection, when no bioluminescent lesions were visible, animals were randomly assigned to one of six different treatment groups: (1) vehicle (control), (2) PRX177561, (3) bevacizumab, (4) PRX177561 plus bevacizumab, (5) sunitinib, and (6) sunitnib plus PRX177561. The presence of a bioluminescent signal was considered to define the disease-free survival (DFS). After 35 days, treatments were stopped and animals were followed for overall survival (OS) determination. Animals were sacrificed when a sign of distress was noticed. a DFS graphical representation in our arms. b Kaplan-Meier rates analyzed for PRX177561 ± bevacizumab. c Kaplan-Meier rates analyzed for PRX177561 ± sunitinib. d Statistical analysis