Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Table 1 Effect of miR-34a reconstitution on DMPM cell tumorigenicity following s.c. injection in SCID mice

Model	miRNA	Engrafted tumors/total mice^a	Tumor onset^b	TV (mm³)	TVI %^c (day)	p value^d
STO	Neg	6/6	1	440 ± 94
STO	miR-34a	6/6	1	188 ± 39	57 (10)	0.0003
MesoII	Neg	5/5	7	201 ± 93
MesoII	miR-34a	5/5	12	9 ± 12	96 (12)	0.0035
MP8	Neg	5/5	18	72 ± 35
MP8	miR-34a	5/5	25	1 ± 2	98 (21)	0.0041

^aNumber of mice presenting s.c. tumors out of number of cell-injected mice
^bMedian day of tumor appearance
^cTumor volume inhibition % in miRNA34a- over Neg-transfected cell-injected mice
^dBy Student’s t test over Neg-transfected cell-injected mice

ISSN: 1756-8722