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Table 1 Effect of miR-34a reconstitution on DMPM cell tumorigenicity following s.c. injection in SCID mice

From: Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Model miRNA Engrafted tumors/total micea Tumor onsetb TV (mm3) TVI %c (day) p valued
STO Neg 6/6 1 440 ± 94   
miR-34a 6/6 1 188 ± 39 57 (10) 0.0003
MesoII Neg 5/5 7 201 ± 93   
miR-34a 5/5 12 9 ± 12 96 (12) 0.0035
MP8 Neg 5/5 18 72 ± 35   
miR-34a 5/5 25 1 ± 2 98 (21) 0.0041
  1. aNumber of mice presenting s.c. tumors out of number of cell-injected mice
  2. bMedian day of tumor appearance
  3. cTumor volume inhibition % in miRNA34a- over Neg-transfected cell-injected mice
  4. dBy Student’s t test over Neg-transfected cell-injected mice