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Fig. 10 | Journal of Hematology & Oncology

Fig. 10

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 10

Cooperation analysis shows that Sirt-1 and caspase-1 do not cooperate in regulating genes with high fold expression changes. a FC/FC plot comparing Log2 FC of genes for meta-Sirt-1 (deletion of Sirt-1 vs. WT or control vs. transgenic Sirt-1 or Sirt-1 treatment) (x-axis) and parallel meta-Caspase-1 KO vs. WT (y-axis). b and c. Further analysis by Ingenuity pathway revealed the top 5 signatures regulated by genes that are cooperated with caspase-1 and Sirt-1 (b) and the pathways regulated by non-cooperation genes (c) (p < 0.05)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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