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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Fig. 3

Caspase-1 does not cooperate with Sirt-1 in regulating genes in mouse liver. a Explanation for the FC/FC plot. Plots distributed in quadrants II and IV represent caspase-1 independently regulated genes from Sirt-1. b Cooperation of Sirt-1 and caspase-1 in the liver. FC/FC plot comparing Log2 FC of genes for Sirt-1 KO vs. WT (x-axis) and parallel caspase-1 KO vs. WT (y-axis). c Significantly changed genes (fold change > 2) regulated by caspase-1 and Sirt-1 deficiency in mouse liver. d The top five signatures of genes regulated by caspase-1 in cooperation with Sirt-1 in the liver. e The top five signatures of genes that are regulated by caspase-1 non-cooperatively with Sirt-1 (p < 0.05) in liver

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Journal of Hematology & Oncology

ISSN: 1756-8722

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