Fig. 2
From: XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy
3D-XPO1 conformations illustrating its interaction with RanGTP, RanGTP-SNUPN, LMB, and KPT-285. (a) Ring-shaped XPO1 is colored blue to red in rainbow colors along the chain from the N-terminus to the C-terminus, showing the C-helix (red) autoinhibitory activity (PDB-ID 4FGV) [96], (b) XPO1 complexed with snurportin 1 (SNUPN) (PDB-ID 3GB8) [27], (c) with RanGTP, in magenta (PDB-ID 5DIS) [97], or (d) with both proteins (PDB-ID 3NC1) [28]. XPO1 inhibitors LMB (e) or KPT-185 (f) (both in red and arrowed) interacting with XPO1-RanGTP-RanBP1 (in gray) (PDB-ID, 4HAT [98], and 4GMX [9])