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Table 2 Unadjusted and sequentially multivariable adjusted risk of principal outcomes in ET and PV patients associated to hs-CRP and PTX-3 values over their respective medians

From: Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera

  Hs-CRP ≥0.8 mg/La PTX-3 ≥4.8 ng/mLa
  OR 95% CI p OR 95% CI p
Thrombosis (n = 55)
 Unadjusted 2.57 1.39–4.75 0.003 0.66 0.37–1.16 0.145
 Adjusted for
  + Male sex 2.57 1.39–4.75 0.003 0.66 0.37–1.16 0.146
  + Age at diagnosis 2.56 1.38–4.73 0.003 0.65 0.37–1.15 0.139
  + PV disease 2.59 1.40–4.81 0.003 0.60 0.34–1.07 0.085
  + Cytoreduction + antiplatelet agents 2.60 1.37–4.95 0.003 0.57 0.31–1.04 0.068
  + JAK2V617F homo 2.60 1.37–4.95 0.003 0.57 0.31–1.04 0.066
Bleeding (n = 43)
 Unadjusted 0.77 0.41–1.45 0.419 1.07 0.57–2.02 0.831
 Adjusted for
  + Male sex 0.77 0.41–1.46 0.428 1.07 0.57–2.01 0.842
  + Age at diagnosis 0.84 0.44–1.61 0.596 1.06 0.56–2.01 0.864
  + PV disease 0.84 0.44–1.62 0.603 0.97 0.50–1.86 0.920
  + Cytoreduction+
antiplatelet agents
0.82 0.43–1.59 0.557 0.95 0.49–1.84 0.883
  + JAK2V617F homo 0.83 0.43–1.60 0.574 0.92 0.48–1.79 0.815
Haematological evolution (n = 33)
 Unadjusted 2.70 1.23–5.95 0.013 1.84 1.02–3.96 0.044
 Adjusted for
  + Male sex 2.66 1.20–5.86 0.015 1.87 1.02–3.99 0.042
  + Age at diagnosis 2.61 1.18–2.88 0.018 1.84 1.01–3.98 0.046
  + PV disease 2.70 1.21–6.01 0.015 1.59 0.72–3.48 0.251
  + Cytoreduction + antiplatelet agents 2.72 1.21–6.15 0.016 1.64 0.74–3.63 0.225
  + JAK2V617F homo 2.79 1.23–6.32 0.014 1.55 0.69–3.46 0.286
Death (n = 56)
 Unadjusted 3.93 2.01–7.68 <.0001 1.58 1.10–2.84 0.039
 Adjusted for
  + Male sex 3.86 1.98–7.55 <.0001 1.61 1.09–2.85 0.041
  + Age at diagnosis 4.45 2.16–9.15 <.0001 1.56 1.05–2.44 0.042
  + PV disease 4.65 2.24–9.65 <.0001 1.14 0.60–2.17 0.680
  + Cytoreduction + antiplatelet agents 5.26 2.47–11.2 <.0001 1.16 0.60–2.22 0.662
  + JAK2V617F homo 5.41 2.53–11.6 <.0001 1.11 0.58–2.15 0.750
  1. OR odds ratio, CI confidence interval, p p value, PV polycythemia vera, ASA acetylsalicylic acid
  2. aReference categories: hs-CRP <0.8 mg/L; PTX3 <4.8 ng/mL
  3. The variables resulted statistically significant are reported in italicized style