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Table 1 EV-associated miRNAs in cancer

From: Extracellular vesicles-mediated noncoding RNAs transfer in cancer

miRNA Cancer type Biological function Mechanism Refs
miR-202-3p CLL Suppress cancer initiation Tumors discard these miRNAs via EVs to [27]
let-7 family Gastric cancer Suppress cancer initiation Promote cancer initiation [21]
miR-146a MM Favor MM cell growth Elevate several cytokines and chemokines [25]
miR-21 Lung cancer Promote angiogenesis Elevate levels of VEGF [30]
miR-21 Lung cancer Regulate immunity Bind as ligands to TLRs in immune cells [53]
miR-21 Ovarian cancer Suppress apoptosis Bind to its target APAF1 [63]
miR-9 Breast cancer Promote angiogenesis Activate JAK-STAT pathway [36]
miR-135b MM Promote angiogenesis Target HIF-1 [37]
miR-939 Breast cancer Destroy endothelial barriers Downregulate VE-cadherin [38]
miR-105 Breast cancer Destroy endothelial barriers Target the tight junction protein ZO-1 [39]
miR-10b Breast cancer Promote cell invasion Suppress its target genes HOXD10 and KLF4 [40]
miR-181c Breast cancer Destroy BBB Downregulate its target gene PDPK1 [43]
miR-200 Breast cancer Promote metastasis Regulate MET process [47]
miR-122 Breast cancer Promote metastasis Reprogram glucose metabolism [49]
miR-29a Lung cancer Regulate immunity Bind as ligands to TLRs in immune cells [53]
miR-203 PC Cause immune dysfunction Regulate TLR4 [54]
miR-212-3p PC Induce immune tolerance Downregulate REXAP expression [56]
miR-221/222 Breast cancer Enhance drug resistance Reduce target gene expression of P27 and ERa [56]
miR-21/155 Neuroblastoma Enhance drug resistance Function as exosomic miR-21/ TLR8/NF-кB/exosomic miR-155/TERF1 axis [57]
miR-143 Prostate cancer Inhibit cell growth Act as a death signal in cell-competitive process [62]