Table 1 Seven pro-angiogenic pathways are included in this study
Pathways | ID | Number of genes | Gene symbol |
|---|---|---|---|
MAPK | (1) | 6 | ETS1 JUN MAPK1 MAPK8 MAPK14 MAP4K4 |
PI3K-AKT | (2) | 8 | AKT1 FOXO1 FOXO3 PIK3CA PIK3CB PIK3CD PIK3CG PTEN |
NOTCH | (3) | 10 | DLL1 DLL3 DLL4 JAG1 JAG2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RBPJ |
NF-κB | (4) | 5 | NFKB1 NFKB2 REL RELA RELB |
JAK-STAT | (5) | 4 | CISH JAK2 STAT1 STAT3 |
HIF-VEGF | (6) | 14 | ARNT EGLN1 EPAS1 FIGF FLT1 FLT4 HIF1A KDR NRP1 NRP2 PGF VEGFA VEGFB VEGFC |
ANG-TIE | (7) | 6 | ANGPT1 ANGPT2 ANGPTL3 ANGPTL4 TEK TIE1 |