Fig. 12

Differential miRNA networks between high- and low-risk patient groups in the Boston cohort. a Differential regulation (“targeting”) by all miRNAs present in the Boston dataset across the two recurrence risk groups (clustering high/low). For comparison, samples with high versus low chemotherapy-induced necrosis do not demonstrate major differences in miRNA targeting. b Network module derived from the 5-miRNA profile. Node size corresponds to the number of edges (connections). Edge thickness is proportional to statistical significance. c The two miRNAs with the highest number of significant edges from the network module shown in b. For both miRNAs, the 20 most differential edges are shown. d Selected candidate drug-gene interaction from the network module. In all networks, red and blue edges indicate edges with higher targeting in the high-risk and low-risk groups, respectively. In c and d, genes upregulated and downregulated in the high-risk group are shown in red and blue, respectively