Fig. 2

DNA damage repair (DDR) and chromatin remodeling gene mutations are associated with increased mutation number and may sensitize tumor to PARP inhibitor. a Patients with higher DDR and chromatin remodeling gene mutations numbers (n = 42) compared with patients with lower mutation numbers (n = 135). The black dotted line marks the median of the distribution. *** (p < 0.001), Mann-Whitney-Wilcoxon rank sum. b Composite image of axial contrast-enhanced computed tomography (CT) slicing through the liver demonstrates a progressive decrease in size of two hepatic metastases prior to treatment (left), 3 months (middle), and 5 months (right) after the initiation of olaparib therapy