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Table 12 12 out of 15 nuclear receptors have anti-inflammatory roles reported in the literature

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Gene name (full name) NRNC symbol Tissue/cell type Purpose Treat Suppressed Induced PMID Inflam.
Cytokines/signaling
Class I—thyroid hormone receptor-like
 THRA NR1A1 Aorta macrophages Atherosclerosis KO IL-1β, NFκB, TNF-α 24797634 Anti
 PPARG NR1C3 Mouse cancer model Tumor growth and angiogenesis Act IL-17 23619236 Anti
 NR1D1 NR1D1 Peritoneal macrophages Aging- or obesity-associated impairment of clockwork and inflammation Act Ccl2, ERK, p38 24307731 Anti
Mice macrophages Circadian clockwork and inflammatory disease KO IL-6 22184247
 NR1H3 NR1H3 Mice plasma and kidney Normal and diabetic kidney KO Nox2, Ncf1, MDA, TLR2, ICAM1, IL-1β, CD68 24201575 Anti
 NR1H2 NR1H2 Mice plasma and kidney Normal and diabetic kidney KO Nox2, Ncf1, TLR2, ICAM1, IL-1β, CD69, MDA(urinary) 24201575 Anti
Macrophage cell line LPS treat Act TNF-α, IL-1β, IL-6, IL-12p40 23099324
ob/ob mouse liver Cellular lipid metabolism Block Cox-2, MCP-1, MIP-2 24206663
 NR1H4 NR1H4 Obese mice liver Obesity-related metabolite disorder Ace Mmp13, Cxcl2, Cxcl8, Cxcl14, IL-1β, IL-6, TNF-α 25425577 Anti
 PPARD NR1C2 Epithelial cells   Act COX-2 24763687 Pro
Class II—retinoid X receptor-like
 RXRA NR2B1 Spleen macrophages Age-related disease Act COX-2, NF-kB, IL-6 24051096 Pro
 NR2F2 NR2F2 Prostate cancer Prostate cancer Act TGF-β 23201680 Anti
Class III—estrogen receptor-like
 ESR1 NR3A1 Male mice Obesity KO IL-10 IL-1β, TNF-α, IL-6 25373903 Anti
Astrocytes Neuroprotective Act CCL2, CCL7 23804112
 ESR3 NR3B2 Mice Intestine tumor KO TGF-β 24104551 Anti
 AR NR3C4 Prostate cancer cells Prostate tumorigenesis KD AKT 25527506 Pro
Hepatocellular carcinoma cells Cell adhesion and migration KO PI3K/AKT 24944078
Class IV—nerve growth factor IB-like
 NR4A1 NR4A1 Macrophages Atherosclerotic lesions KO IL-4 23288947 Anti
Bone marrow-derived macrophages (BMM) Atherosclerotic lesions KO IL-12, IFN-δ, SDF-1α 22194623
Macrophage Atherosclerotic lesions KO TNF-α, TLR-4, NFκB 22194622
 NR4A3 NR4A3 Mast cells Vascular biology and inflammation KO IL-13, MCP-1, TNF-α 24586680 Anti
Hematopoietic stem cells Atherosclerotic lesions KO Ly6C(+) monocytes 24806827
Endothelial cells Atherosclerotic lesions KO VCAM-1, ICAM-1 20558821
Class O—miscellaneous
 NR0B2 NR0B2 Mice kidney Inflammasome KO IL-1β, IL-18, NLRP3, ASC 25655831 Anti
  1. Abbreviations: KO knockout, Act activation, Ace acetylation, Cxcl Cxc ligand, IL interleukin, MCP monocyte chemotactic protein, Mmp matrix metallopeptidase, TLR Toll-like receptor, VCAM vascular cell adhesion molecule, ICAM intercellular adhesion molecule, Inflam inflammation, Anti anti-inflammatory, Pro pro-inflammatory