A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 15 A large nuclear receptor is downregulated in proatherogenic mouse models ApoE−/−, LDL-R−/−, and type 2 diabetes mouse model db/db

Disease	Tissue/cell type	Number		Upregulated gene	Fold*	Downregulated gene	Fold*	PMID/GEO ID
Disease	Tissue/cell type	Up	Down		∆		∆	PMID/GEO ID
ApoE−/− 8-week HFD	Aortic arch	0	1			Nr2f1	−1.2	20577049/GSE18443
ApoE−/− 24-week HFD		2	4	Nr1h3	1.26	Nr1a2	−1.25
				Nr1i1	1.27	Nr1b2	−1.2
						Nr1d1	−1.28
						Nr3a1	−1.22
LDL-R−/− VS. WT	Macrophages of aorta	2	9	Nr1c3	1.29	Nr1a2	−1.3	21868699/GSE24342
				Nr3a1	1.3	Nr1b2	−1.2
						Nr1d2	−1.28
						Nr1i1	−1.3
						Nr2b3	−1.25
						Nr3c1	−1.2
						Nr3c4	−1.27
						Nr4a1	−1.32
						Nr4a2	−1.28
db/db VS. WT	Glomerular endothelial cell	1	3	Nr1b2	1.74	Nr1i1	−1.47	20706631/GSE21324
						Pgr	−1.52
						Ar	−1.67

Abbreviations: WT wild type, ApoE−/− apolipoprotein E-deficient mice; LDL-R−/− low-density lipoprotein receptor deficient mice, db/db mice leptin receptor gene mutant mice, HFD high fat diet, VS. versus
*Fold change > 1.2

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