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Table 15 A large nuclear receptor is downregulated in proatherogenic mouse models ApoE−/−, LDL-R−/−, and type 2 diabetes mouse model db/db

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Disease Tissue/cell type Number Upregulated gene Fold* Downregulated gene Fold* PMID/GEO ID
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ApoE−/− 8-week HFD Aortic arch 0 1    Nr2f1 −1.2 20577049/GSE18443
ApoE−/− 24-week HFD 2 4 Nr1h3 1.26 Nr1a2 −1.25
   Nr1i1 1.27 Nr1b2 −1.2
     Nr1d1 −1.28
     Nr3a1 −1.22
LDL-R−/− VS. WT Macrophages of aorta 2 9 Nr1c3 1.29 Nr1a2 −1.3 21868699/GSE24342
Nr3a1 1.3 Nr1b2 −1.2
   Nr1d2 −1.28
   Nr1i1 −1.3
   Nr2b3 −1.25
   Nr3c1 −1.2
   Nr3c4 −1.27
   Nr4a1 −1.32
   Nr4a2 −1.28
db/db VS. WT Glomerular endothelial cell 1 3 Nr1b2 1.74 Nr1i1 −1.47 20706631/GSE21324
   Pgr −1.52
   Ar −1.67
  1. Abbreviations: WT wild type, ApoE−/− apolipoprotein E-deficient mice; LDL-R−/− low-density lipoprotein receptor deficient mice, db/db mice leptin receptor gene mutant mice, HFD high fat diet, VS. versus
  2. *Fold change > 1.2