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Table 23 Nuclear receptor expression was regulated by ApoE and LDL-R, pro/anti-inflammatory cytokines, and inflammasomes in pathology

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Human metabolic disease NRNC symbol ApoE KO LDL-R KO IFN-γ stimulation IL-1β stimulation TNF-α stimulation NFκB inhibitor TGF-β KO Tg-PPARα CAS1 KO ASC KO Tg-Sirt1 NLRP3 mutant
Upregulation (from Fig 6c) NR0B1             
NR1B1          
NR1B3         
NR1F3           
NR1I1         
NR2F6         
NR3B2            
NR4A1        
NR5A1            
NR4A2          
NR6A1           
NR4A3           
Downregulation (from Fig 6c) NR1A1         
NR1B2       
NR1C1            
NR1D1           
NR1H3           
NR3C3           
NR1F1        
NR1C3        
NR3A1        
NR2C2          
NR3C4        
NR1F2          
NR3B3          
NR3C1       
NR2A2           
NR2B3         
NR2C1         
NR2E3            
NR2F1         
NR3A2          
  1. Abbreviations: KO knockout, ApoE apolipoprotein E, LDL-R−/− low-density lipoprotein receptor, IFN-γ interferon gamma, IL-1β interleukin 1 beta, TNF-α tumor necrosis factor-α-like; TGF-β transforming growth factor-β, Casp1−/− caspase-1-deficient mice; ASC−/− PYD and CARD domain-containing deficient mice, Tg-Sirt1 transgenic sirtuin 1 mice, NLRP3 NLR family pyrin domain containing 3 deficient mice, PBMC peripheral blood mononuclear cells