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Table 1 Molecular mutation ratios of patients younger than 40 years old in MRC AML10 and AML12 and our cohort

From: Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population

 

MRC AML10 and AML12

China1a

P value (MRC vs. China1)

Age range, years

MUT, no.

WT, No.

MUT/total, %

Median age (range), years

MUT, no.

WT, No.

MUT/total, %

FLT3-ITD [9]

15–34

68

222

23.4

36 (15–55)

66

522

11.2

< 0.001

FLT3-TKD [10]

15–39

46

412

10.0

36 (15–55)

51

534

8.72

0.464

DNMT3a [11]

15–39

71

287

19.8

36 (15–55)

38

348

9.84

< 0.001

CEBPA [12]

15–39

49

524

8.6

36 (15–55)

116

442

20.8

< 0.001

CEBPA double [12]

15–39

33

540

5.8

36 (15–55)

75

483

13.4

< 0.001

CEBPA single [12]

15–39

16

557

2.9

36 (15–55)

41

517

7.3

< 0.001

  1. Abbreviations: WT wild type, MUT Mutant
  2. aData from our cohort (ChiCTR-TRC-10001202)
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Journal of Hematology & Oncology

ISSN: 1756-8722

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