Skip to main content

Table 2 Stem cell source, GVHD prophylaxis, and conditioning regimens

From: Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT

 

Haplo, n (%)

MUD 10/10, n (%)

p value

Stem cell source

 BM

129 (52)

167 (6)

< 10−4

 PBSC

121 (48)

2422 (94)

 

 Missing

0

0

 

GVHD prophylaxis

 Csa based

4 (2)

426 (17)

< 10−4

 Csa + Mtx

9 (4)

656 (26)

 

 Csa + Mmf ± others

12 (5)

1123 (44)

 

 CSA + MMF ± MTX

16 (7)

29 (1)

 

 Tacro alone

1 (0)

20 (1)

 

 Mmf + Tacro/Mmf + Siro

38 (16)

185 (7)

 

 Mtx + Tacro

0 (0)

44 (2)

 

 Pt-Cy based

156 (65)

22 (1)

 

 Others

14 (1)

84 (1)

 

In vivo TCD

 No

181 (74)

648 (25)

< 10−4

 Yes

63 (26)

1915 (75)

 

 Missing

6

26

 

Conditioning regimens

MAC

66 (27)

591 (23)

0.238

 Bu-Cy/BuFlu

7

253

 

 TBF

31

8

 

 Flu-Mel

7

81

 

 TBI based

4

61

 

 Other

17

188

 

RIC

182 (73)

1948 (77)

 

 Bu-Flu

10

635

 

 TBF

55

19

 

 Flu-Mel

9

414

 

 TBI based

55

457

 

 Other

53

423

 
  1. Abbrevations: Haplo, haploidentical; MUD, matched unrelated donor; BM, bone marrow; PBSC, peripheral blood stem cell; GVHD, graft versus host disease; CSA, cyclosporine; MTX, methotrexate; MMF, mycophenolate; TACRO, tacrolimus; SIRO, sirolimus; PTCY, post-transplant cyclophosphamide; TCD, T-cell depletion; MAC, myeloablative conditioning; BU, busulphan, CY, cyclophosphamide; FLU, fludarabine; TBF, thiotepa busulphan fludarabine; MEL, melphalan; TREO, treosulphan; FLAMSA, fludarabine, amsacrine, and cytarabine; TBI, total body irradiation; RIC, reduced intensity conditioning