Fig. 2

Effects of HMA and cytostatic drug combinations. Cells were treated with HMA in the absence or presence of AraC (a) or Doxo (b). Cytostatic drugs (CTX) were added simultaneously, 24 h before, or 24 h after treatment with HMA. CTX concentrations were based on low doses and used as follows: 100 nM AZA (SEM), 500 nM AZA (RS4;11), 100 nM DEC (SEM), 500 nM DEC (RS4;11); 10 nM AraC (SEM); 2500 nM AraC (RS4;11), 12.5 nM Doxo (SEM, RS4;11). The metabolic activity was determined 72 h after drug application. Significant effects are marked with * when metabolic activity decreased significantly (p < 0.05) compared at once to DMSO, HMA, and CTX