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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: STARD13-correlated ceRNA network-directed inhibition on YAP/TAZ activity suppresses stemness of breast cancer via co-regulating Hippo and Rho-GTPase/F-actin signaling

Fig. 6

STARD13-correlated ceRNA network regulates breast CSC traits through LATS1/2. a and b Western blot analysis of lysates from MDA-MB-231 with STARD13- or its ceRNAs-3′UTR overexpression plus LATS1 or LATS2 or LATS1/2 knockdown by lentiviral infection. c Phase contract images of mammospheres formed by MDA-MB-231 cells described in a. Depletion of LATS1 or LATS2 or LATS1/2 rescued the mammosphere formation impaired by enforced STARD13-correlated ceRNAs-3′UTR expression in MDA-MB-231 cells. d Quantification of mammosphere formation in c. Data were presented as the mean ± SD, n = 3, *p < 0.05, **p < 0.01 vs. pLVX-Ctrl

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