Fig. 6

miR-519a was associated with chemoresistance. a miR-519a expression was assessed in primary (n = 24) and recurrent GBM tissue samples (n = 24). b Expression levels of miR-519a were inversely correlated with STAT3 mRNA in tissue samples, as measured by linear regression analysis. c Expression of STAT3, LC3B, and cleaved caspase-3 in primary and recurrent GBM tissue samples were determined by immunochemical staining (magnification × 200). d Schematic illustration of the mechanisms underlying miR-519a induced chemosensitivity to TMZ. Pointed arrows and blunted arrows indicate both activation and repression, respectively. *p < 0.05, **p < 0.01