Fig. 3

The synthesis and working principle of Nano-sar. a Schematic representation of the self-assemble Nano-sar and its disassembly upon CTSB digestion. b Schematic illustration of the working principle of Nano-sar for targeting tumor cells. c Solid-phase synthesis of peptide for Ac-K(Boc)GFLG-OH as a CTSB-cleavable linker. d Chemical structure of linear-dendritic polymeric drug carrier and saracatinib. e Saracatinib-loaded formulation to form nanoscale assembly as characterized by DLS. f The drug release profile at various conditions determined by HPLC