From: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
Identified/putative target mRNAs | Cis-element on RNA | Regulation of IGF2BP1 for target mRNA | The biological roles of those target mRNAs (http://www.genecards.org/) | Ref. |
---|---|---|---|---|
eEF2 | Increasing basal protein translation rates | Enhancing basal proliferation rates | [102] | |
CD44 | 3′-UTR | Stabilization of the transcript | Involving in invadopodia formation, cell migration, tumor growth and progression. | [83] |
c-Myc | CDS | Inhibition of CRD-dependent mRNA decay | Promoting the tumor cell proliferation | [40] |
ACTB | 3′-UTR | Inhibition of mRNA translation; | Involving in various types of cell motility | [101] |
IGF2 | 5′-UTR | Inhibition of mRNA translation | Promoting cell growth and proliferation | [8] |
PTEN | CDS | Inhibition of CRD-dependent mRNA decay | Modulation of actin dynamics and cell migration; modulating cell cycle progression and cell survival; promoting cell polarization and directed movement. | [100] |
MDR1 | CDS | Inhibition of CRD-dependent mRNA decay | NA | [8] |
MAPK4 | 3′-UTR | Inhibition of mRNA translation | Modulating actin dynamics and cell migration; promoting entry in the cell cycle | [100] |
PPP1R9B | 3′-UTR | mRNA transport | Involving in linking the actin cytoskeleton to the plasma membrane at the synaptic junction | [8] |
BTRC | CDS | Inhibition of betaTrCP1 mRNA degradation | Mediating the ubiquitination and subsequent proteasomal degradation of target proteins | [102] |
CTNNB1 | 3′-UTR | Inhibition of mRNA decay | Regulating cell adhesion; promoting neurogenesis | [8] |
KRAS | CDS, 3′-UTR | Inhibition of mRNA decay | Modulating cell proliferation; promoting oncogenic events | |
PABPC1 | 5′-UTR | mRNA translation | Regulating mRNA metabolism, and translationally coupled mRNA turnover | [29] |
H19 | 3′-UTR | mRNA localization | Involving in migration and invasion | [29] |
GLI1 | CDS | Inhibition of mRNA decay | Regulating cell proliferation and differentiation; promoting cancer cell migration | [29] |
cIAP1 | 5′-UTR IRES | Enhancing IRES-mediated translation | Modulating cell proliferation, as well as cell invasion and metastasis, and cell cycle | [77) |
RAPGEF2 | Inhibiting cell proliferation of melanoma cells and promotes their apoptosis; regulating embryonic blood vessel formation; establishment of basal junction integrity and endothelial barrier function | [100] | ||
RPS6KA5 | Involving in neuronal cell death; limiting the production of pro-inflammatory cytokines | [100] | ||
RSK2 | Stabilization of the transcript | Promoting cell migration and invasion | [99] | |
PPME1 | Stabilization of the transcript | Promoting cell migration and invasion | [99] | |
ITGA6 | NA | NA | Mediating cell adhesion to extra cellular matrix or to other cells, and fertilization of ova and embryonic development | [28] |
ETV6/RUNX1 mRNA (potential) | Stability of this transcript | NA | [97] | |
GDF15 | 3′-UTR | Inhibition of this transcript | Inhibiting breast cancer cell migration and invasion | [17] |
RGS4 | Inhibiting signal transduction and breast cancer cell migration and invasion | [17] | ||
PTGS2 | Modulating production of inflammatory prostaglandins, and motility, proliferation, and resistance to apoptosis. | [17] | ||
CDH1 | Localization of the mRNAs | Regulating cell–cell adhesions, mobility, and proliferation of epithelial cells; downregulation of cell growth | [53] | |
β-actin | Localization of the mRNAs | Involving in establishment of cell polarity and cell motility | [53] | |
α-actinin | Localization of the mRNAs | Regulating focal adhesion metabolism | [53] | |
Arp2/3 | Localization of the mRNAs | Regulating focal adhesion metabolism, actin polymerization, and the formation of branched actin networks | [53] | |
TAU | 3′-UTR | Localization of the mRNAs | Promoting microtubule assembly and stability; establishment and maintenance of neuronal polarity | [53] |
MKI67 | Stability of this transcript | Promoting the tumor cell proliferation | [40] |