Fig. 4

SNHG7 promotes cell migration, invasion, vasculogenic mimicry of CRC cells in vitro, and proliferation in vivo. a, b The cell migration rates were determined by performing wound healing and transwell assay. c Transwell invasion assays were performed. d The abilities of neovascularization were determined by endothelial tube formation assay. e Effects of SNHG7 overexpression on tumor growth in vivo. Left: images of tumors in nude mice injected with SNHG7-overexpressed SW480 cells. Middle: tumor weights. Right: tumor growth curves. f Effects of SNHG7 knockdown on tumor growth in vivo. Left: images of tumors in nude mice injected with shSNHG7 SW620 cells. Middle: tumor weights. Right: tumor growth curves. g, h Ki67 was detected by IHC assay. The error bars in all graphs represented SD, and each experiment was repeated thrice. *P < 0.05, **P < 0.01, ***P < 0.001