Table 3 Univariate and multivariate Cox regression analyses of clinicopathological features association with prognosis of 53 CRC patients (cohort 1)
Variables | Subset | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Age (years) | < 60 vs. ≥ 60 | 1.379(0.525–2.484) | 0.495 | – | – |
Gender | Male vs. female | 1.514(0.701–2.916) | 0.410 | – | – |
Tumor size | < 5 cm vs. ≥ 5 cm | 2.438(1.003–5.105) | 0.062 | – | – |
Tumor location | Colon vs. rectum | 1.028(0.712–1.582) | 0.875 | – | – |
Histologic grade | Well/moderately vs. poorly/others | 1.847(0.571–2.896) | 0.289 | – | – |
Depth of invasion | T1,T2 vs. T3,T4 | 2.561(0.911–4.616) | 0.124 | – | – |
Lymphatic metastasis | Absent vs. Present | 3.054(1.008–5.531) | 0.028* | 2.313(0.869–4.012) | 0.045* |
Venous invasion | Absent vs. Present | 1.478(0.491–3.292) | 0.353 | – | – |
Distant metastasis | Absent vs. Present | 3.681(1.308–5.928) | 0.004* | 3.163(1.586–5.275) | 0.011* |
Tumor stage | I-II vs. III-IV | 4.422(1.849–8.241) | < 0.001* | 3.549(1.301–6.684) | 0.002* |
SNHG7 expression | Low vs. high | 3.317(1.331–5.609) | 0.008* | 2.924(1.035–5.268) | 0.030* |