The roles of metallothioneins in carcinogenesis

Table 3 Roles of MTs in carcinogenesis

MT isoforms	Mechanisms	References
MTs	Regulation of P53 activity	[22, 46, 137,138,139, 141]
MTs	Regulation of NF-κB activity	[47,48,49, 135, 142]
MTs	Methylation of DNA promoters	[7, 10, 143,144,145,146,147,148,149,150,151,152, 154, 204]
MT1H	Increasing the methyltransferase activity of EHMT1 on histone 3	[26]
MT1G	Modulation of the PI3K/AKT and Rb/E2F signaling pathways	[89]
MT1, MT2A	Modulation of the PI3K/AKT signaling pathway	[25]
MT1H	Suppression of the Wnt/β-catenin signaling pathway	[8]
MT1G	Allelic loss on chromosome 16q12.1-q23.1	[155]
MT1F	Loss of heterozygosity	[52]
MT2A	SNP (rs28336003)	[14]

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