Table 3 The potential clinical applications of deregulated lncRNAs in EC

Diagnostic biomarker

POU3F3

Up

–

Plasma of 147 ESCC patients and 123 healthy donors

[148]

Linc00152, CFLAR-AS1, and POU3F3

Up

Poor post-surgery prognosis

Plasma of 205 ESCC patients, 82 esophagus dysplasia patients and 210 healthy donors

[149]

MIR31HG

Down

TNM stage, lymphatic metastasis, and poorer OS

Plasma of 205 ESCC patients and 39 healthy donors

[153]

Prognostic biomarker

ATB

Up

TNM stage and poor DFS

150 paired ESCC tissues

[51]

XIST

Up

Shorter DFS and OS

127 paired ESCC tissues

[74]

AK001796

Up

TNM stages, lymph node metastasis, and shorter OS

50 paired ESCC tissues

[93]

ZEB1-AS1

Up

Tumor grade, depth of invasion, lymph node metastasis, and shorter DFS and OS

87 paired ESCC tissues

[145]

MALAT1

Up

Lymphatic invasion, distant metastasis, tumor differentiation, and shorter OS

106 paired ESCC tissues

[147]

PCAT-1

Up

Lymph node metastasis, TNM stage, and poorer OS

130 paired ESCC tissues

[161]

NKILA

Down

Tumor size, TNM stage, poor DFS, and OS

137 paired ESCC tissues

[162]

SPRY4-IT1

Up

Clinical stage and shorter OS

92 paired ESCC tissues

[163]

ZFAS1

Up

Poor OS

50 paired ESCC tissues

[164]