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Table 5 Clinical scenarios of metastatic cancer patients with no detectable ctDNA (i.e., MSAF = 0)

From: Clinical utility of tumor genomic profiling in patients with high plasma circulating tumor DNA burden or metabolically active tumors

Pt No. Age (years old) Gender Race/ethnicity Diagnosis Cohort (A = frozen plasma; B=fresh blood) cfDNA ng/mL GA MAF (%) MSAF RECIST V1.1 (cm) Total SUVmax Clinical scenario
Pt 1 59 F Not Hispanic, White Breast, IDC B 0.55 No reportable GA 0 1.8 N/A CR
Pt 2 52 F Not Hispanic, Asian LUAD B 4.20 No reportable GA 0 2.3 1.1 CR
Pt 3 68 M Not Hispanic, White LUAD B 0.49 No reportable GA 0 2.5 2.6 CR
Pt 4 54 M Not Hispanic, Filipino LUAD B 12.21 No reportable GA 0 6.2 5.8 CR
Pt 5 65 F Not Hispanic, White LUAD B 0.75 No reportable GA 0 7.3 14.4 CR
Pt 6 68 M Not Hispanic, White LUSC A 0.21 No reportable GA 0 20.5 52.9 *CR (ongoing at 3 years), pneumonitis
Pt 7 55 F Not Hispanic, Asian LUAD B 2.94 TP53 E358V (49.1%) 0 2.3 4.3 PR
Pt 8 73 F Not Hispanic, White LUAD B 7.25 BRCA2 S1121* (44.6%) 0 7.9 14.6 PD vs inflammation
Pt 9 68 F Not Hispanic, White LUAD B 182.16 No reportable GA 0 5.8 34.1 PD vs inflammation
Pt 10 84 M Not Hispanic, White LUAD B 9.04 No reportable GA 0 7.7 30.2 Small volume, indolent disease
Pt 11 67 F Not Hispanic, Iran Breast, inflammatory B 5.93 No reportable GA 0 9.6 11.3 Small volume, indolent disease vs pneumonia
Pt 12 54 M Not Hispanic, Filipino LUAD B 0.05 No reportable GA 0 10.8 32.0 Small volume, indolent disease vs pneumonia
  1. CR complete response, cfDNA cell free DNA, F female, GA genomic alteration, IDC invasive ductal carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, M male, MAF mutation allele frequency, MSAF maximum somatic allele frequency, NA not available, PR partial response, Pt patient, RECIST Response Evaluation Criteria in Solid Tumors, SD stable disease, SUVmax maximum standardized uptake value
  2. *Biopsy proven new tumor without treatment effect and immune related pneumonitis in different areas of the lung