Table 5 Clinical scenarios of metastatic cancer patients with no detectable ctDNA (i.e., MSAF = 0)
Pt No. | Age (years old) | Gender | Race/ethnicity | Diagnosis | Cohort (A = frozen plasma; B=fresh blood) | cfDNA ng/mL | GA MAF (%) | MSAF | RECIST V1.1 (cm) | Total SUVmax | Clinical scenario |
|---|---|---|---|---|---|---|---|---|---|---|---|
Pt 1 | 59 | F | Not Hispanic, White | Breast, IDC | B | 0.55 | No reportable GA | 0 | 1.8 | N/A | CR |
Pt 2 | 52 | F | Not Hispanic, Asian | LUAD | B | 4.20 | No reportable GA | 0 | 2.3 | 1.1 | CR |
Pt 3 | 68 | M | Not Hispanic, White | LUAD | B | 0.49 | No reportable GA | 0 | 2.5 | 2.6 | CR |
Pt 4 | 54 | M | Not Hispanic, Filipino | LUAD | B | 12.21 | No reportable GA | 0 | 6.2 | 5.8 | CR |
Pt 5 | 65 | F | Not Hispanic, White | LUAD | B | 0.75 | No reportable GA | 0 | 7.3 | 14.4 | CR |
Pt 6 | 68 | M | Not Hispanic, White | LUSC | A | 0.21 | No reportable GA | 0 | 20.5 | 52.9 | *CR (ongoing at 3Â years), pneumonitis |
Pt 7 | 55 | F | Not Hispanic, Asian | LUAD | B | 2.94 | TP53 E358V (49.1%) | 0 | 2.3 | 4.3 | PR |
Pt 8 | 73 | F | Not Hispanic, White | LUAD | B | 7.25 | BRCA2 S1121* (44.6%) | 0 | 7.9 | 14.6 | PD vs inflammation |
Pt 9 | 68 | F | Not Hispanic, White | LUAD | B | 182.16 | No reportable GA | 0 | 5.8 | 34.1 | PD vs inflammation |
Pt 10 | 84 | M | Not Hispanic, White | LUAD | B | 9.04 | No reportable GA | 0 | 7.7 | 30.2 | Small volume, indolent disease |
Pt 11 | 67 | F | Not Hispanic, Iran | Breast, inflammatory | B | 5.93 | No reportable GA | 0 | 9.6 | 11.3 | Small volume, indolent disease vs pneumonia |
Pt 12 | 54 | M | Not Hispanic, Filipino | LUAD | B | 0.05 | No reportable GA | 0 | 10.8 | 32.0 | Small volume, indolent disease vs pneumonia |