Fig. 4

The sensitivity to trametinib is associated with RAS mutation. a Cells were cultured for 4 days with increasing concentrations of trametinib, and the sensitivity was determined by the area under the curve using the MTT assay and expressed as z-score. Analysis was performed as a function of mutations in the MAPK pathway (Mann–Whitney test). b Trametinib response associated with dysregulation in the MAPK pathway. Robust linear regression is displayed; regression line was drawn according to coefficients obtained after 5000 bootstrapped replicates. Points were jittered for clarity