Fig. 3
Anti-tumor effect of dual PI3K/mTOR inhibition in IB136 and resIB136-derived xenografts in Ragγ2C−/− mice. a Tumor volume progression curves over 3 weeks of BEZ235 treatment. Mice were randomly assigned to receive 40 mg/kg of BEZ235 or vehicle. The data points represent an average from 8 mice (bars, SEM). *p < 0.05; ***p < 0.001, two-way ANOVA. b Kaplan-Meier curves for tumor doubling times. c Immunohistochemical staining images of tumor samples treated with anti-Ki-67 and anti-pS6RPser240/244 antibodies (objective magnification, × 10). Percentages correspond to positively stained cells estimated by a pathologist