Skip to main content
Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

Fig. 4

SPAG5 knockdown results in enhanced sensitivity to olaparib. a CCK8 assays showed IC50 values for olaparib in SPAG5 overexpression MDA-MB-231 and MDA-MB-468 cells and SPAG5 knockdown Hs-578t and BT549 cells. b CCK-8 assays showed overexpression of SPAG5 reduced the efficiency of olaparib in MDA-MB-231 cells, while knockdown of SPAG5 increased the efficiency of olaparib in Hs-578t cells. c Western blot of SPAG5, RAD51, and BRCA2 in MDA-MB-231and MDA-MB-468 cells treated with SPAG5 overexpression and Hs-578t and BT549 cells treated with SPAG5 siRNAs

Back to article page

Journal of Hematology & Oncology

ISSN: 1756-8722

Contact us