Fig. 6
From: The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo
TL/Btz circumvents microenvironment-driven intrinsic resistance. a GFP-labeled PS-R cells co-cultured with or without BM stromal HS-5 cells and were incubated with Btz +/− TL for 48 h. Apoptosis of GFP+ cells was analyzed by multi-color flow cytometry of 7-AAD staining. b Cells were stained with 7-AAD to monitor death of GFP+ cells. Bright field images were captured with an IX71-Olympus inverted system microscope at × 200 magnification. NS, not significant