CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Table 1 Correlation between clinicopathological parameters of patients enrolled

Clinical characteristics	No. of patients (n = 189)	CD73 low	CD73 high	P
Age, years
≤ 50	79	35	44	0.033
> 50	110	66	44	0.033
Sex
Female	38	16	22	0.117
Male	151	85	66	0.117
Child–Pugh score
A	179	96	83	0.823^#
B	10	5	5	0.823^#
Liver cirrhosis
No	42	20	22	0.391
Yes	147	81	66	0.391
ALT, U/L
≤ 40	134	71	63	0.845
> 40	55	30	25	0.845
AST, U/L
≤ 40	135	73	62	0.782
> 40	54	28	26	0.782
AFP, ng/ml
≤ 400	140	74	66	0.786
> 400	49	27	22	0.786
No. of tumors
Single	169	92	77	0.424
Multiple	20	9	11	0.424
Tumor size, cm
≤ 5	119	62	57	0.631
> 5	70	39	31	0.631
Tumor encapsulation
Complete	123	59	64	0.040
None	66	42	24	0.040
Satellite lesion
No	171	88	83	0.093
Yes	18	13	5	0.093
Macrovascular invasion
No	175	94	81	0.784
Yes	14	7	7	0.784
Microvascular invasion
No	107	64	43	0.045
Yes	82	37	45	0.045
Edmondson stage
I-II	126	74	52	0.039
III-IV	63	27	36	0.039
BCLC stage
0 + A	158	86	72	0.537
B + C	31	15	16	0.537

ALT alanine aminotransferase, AST aspartate transaminase, AFP α-fetoprotein, BCLC Barcelona Clinic Liver Cancer
Bold indicated statistical significance

ISSN: 1756-8722