Fig. 3

Results of posted and pending trials of PD-1/PD-L1 inhibitors between lung adenocarcinoma and squamous carcinoma regarding different PD-L1 expression. All posted and pending trials were stratified based on the indication for different expression of PD-L1 and treatment lines. Only PD-1/PD-L1 inhibitors of pembrolizumab, nivolumab, atezolizumab, durvalumab, and avelumab were included except for checkpoint inhibitors from Chinese pharmaceutical companies due to early phase trials of these checkpoint inhibitors for lung cancer. Checkmate-227, although regardless of PD-L1 expression, required high tumor mutation burden (TMB)