Fig. 5

Ilamycin C suppresses IL-6/STAT3 pathway in TNBC cells. a The expression of basal p-JAK2 and p-STAT3 in TNBC cell lines (MDA-MB-231, BT-549), non-TNBC cell lines (MCF7), and normal breast cell lines (MCF10A). b The basal p-JAK2 and p-STAT3 were reduced after the treatment of Ilamycin C for 24 h. c Decreased level of p-STAT3 in nucleus after the treatment of Ilamycin C for 24 h. d Ilamycin C prevented IL-6-induced p-JAK2 and p-STAT3 in MDA-MB-231 and BT-549 cells after the treatment of Ilamycin C for 24 h