Fig. 5
From: Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
Analysis of combinations effects on proliferation and CD11b expression levels. a IC50-based isobologram analysis of inhibitor combinations in MOLM-13 cells after 4 days of treatment. The diagonal lines indicate additivity. Experimental data points, represented by dots (square, triangle, and circle) indicate biological replicates. b CD11b expression level after BAY-155 (0.15 μM)–Brequinar (0.64 μM), BAY-155 (0.15 μM)–EPZ-5676 (0.64 μM), Brequinar (0.15 μM)–EPZ-5676 (0.64 μM), and Brequinar (0.15 μM)–OTX015 (0.15 μM) combinations in MOLM-13 cells after 4 days of treatment. Data shows a representative concentration. Bar charts show an average of three biological replicates, the orange line indicates predicted additive effect, error shows SD, statistics ***P < 0.001, **P < 0.01, *P < 0.05, n.s. P < 0.05, two-sided t test. c Graphical summary