Drug | Class | Patient population | N | ORR | CR | Grade 3 AE | Reference |
---|---|---|---|---|---|---|---|
M7583 | BTK inhibitor | R/R DLBCL, WM, MCL, MZL, SLL | 18 | 50% | 11% | Diarrhea | [80] |
ME-401 | PI3Kδ | R/R FL, CLL | 31 | 83% | NA | Diarrhea, rash | [81] |
LAM-002A | Endosomal protein inhibitor | R/R DLBCL, MCL, FL, MZL, CLL | 24 | NA | NA | Tumor lysis syndrome | [82] |
INCB057643 | BET protein inhibitor | R/R FL, DLBCL | 5 | 33% (DE) | None | Hyperglycemia, thrombocytopenia, anemia, hyperbilirubinemia, Increased INR | [83] |
MRG-106 | miR-155 inhibitor | Mycosis fungoides | 38 | NA | NA | Pruritus, tumor flare | [84] |
DS-3201b | EZH1/2 dual inhibitor | PTL, AITL, DLBCL, FL, MZL | 15 | 53% | 6.6% | Pneumonia | [85] |
Apatinib | VEGFR-2 tyrosine kinase inhibitor | R/R NHL | 21 | 47.6% | 9.5% | None | [86] |