Table 3 PD-L1 expression in SCLC
Author | Patientsc | IHC assay | Biopsy types | TC PD-L1 cutoff | Cell type | PD-L1 expression |
|---|---|---|---|---|---|---|
Antonia et al. [57] | 146 | 28-8/Dako | Archival or fresh | 1% 5% | Tumor cell | 16.4% 4.8% |
Ott et al. [71] | 145 | 22C3/Dako | Archival or fresh | 1% | Tumor and Stromal cell | 31.7% |
Hyun et al. [72] | 92 | 22C3/Dako | Archival or fresh | 1% | Tumor and stromal cell | 45.7% |
Inamura et al. [77] | 74 | E1 L3N/CST | Archival | 5% | Tumor cell | 18.9% |
Yasuda et al. [78] | 39 | 22C3/Dako | Archival | 1% | Tumor cell | 2.5% |
Pujol et al. [63] | 53 | SP142/Ventana | Archival | 1% | Tumor and stromal cell | 2% |
Gadgeel et al. [66] | 30 20 | 22C3/Dako | Archival | 1% | Tumor cell Stromal cell | 10% 40% |
Schultheis et al. [79]. | 94d | 5H1/Chen’s lab E1 L3N/CST | Archival | 1% | Tumor cell Stromal cell | 0.0% TIMs, 18.5% TILs, 48% |
Berghoff et al. [41] | 32 | NA/Dako | Archival | 5% | Tumor cell Stromal cell | 34.4% TIMs, 28.1% TILs, 25.0% |
Yu et al. [80] | 194e | SP142/Ventana 28-8/Dako | Archival | 1% | Tumor cell Stromal cell | 16.5% TILs, 56.2%, 44.8% |
Kim et al. [81] | 120 | MAB1561/ R&D system | Archival | 1% | Tumor cell Stromal cell | 14.2% TILs, 23.3% |
Komiya et al [82] | 99 | EPR1161/Abcam | Archival | 5% | Tumor cell | 82.8% |
Ishii et al. [83] | 102 | NA/Abcam | Archival | 5% | Tumor cell | 71.6% |