Fig. 2
From: MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer
MET protein structure (a) and HGF/MET signaling pathway (b). GRB, growth factor receptor-bound protein; SHC, Src homology 2 domain-containing; PI3K, phosphatidylinositol 3-kinase; SOS, son of sevenless; SHP2, Src homology region 2-containing protein tyrosine phosphatase 2; FAK, focal adhesion kinase