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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Fig. 7

Anti-proliferative effect of combined inhibition of BET and HDAC in DHL and THL. a–f WT-MYC (U2932), DHL (LY1), and THL (Val) DLBCL cell lines were treated with I-BET alone, SAHA alone, and combination of both and proliferation and survival analyzed by H3-thymidine incorporation and annexin/PI, respectively. g The effect on P21, H3K27AC, BCL-XL, and MCL-1 expression was determined by western blotting. Bar represents mean ± SD from three separate experiments. p < 0.05, **p < 0.01

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