Table 1 Identification of MYC, BCL-2, and BCL-6 rearrangements in human DLBCL and BL cell lines: c-MYC, BCL-2, and BCL-6 rearrangements were analyzed with break-apart FISH in human DLBCL (n = 9) and Burkitt Lymphoma cell lines (n = 2)
DLBCL cell lines | cMYC | BCL-2 | BCL-6 | Status |
|---|---|---|---|---|
U2932 | Wild-type | Amplification | 3–4 copies | WT-MYC |
HBL-1 | Wild-type | 3 copies | Normal | WT-MYC |
Raji (BL) | Rearrangement | 3 copies | Normal | Single hit |
Ramos (BL) | Rearrangement | 1 copy | 3 copies | Single hit |
SUDHL2 | Rearrangement/amplification | Rearrangement | 3 copies | Double hit |
OCILY1 | Rearrangement/amplification | Rearrangement | 3 copies | Double hit |
OCILY10 | Rearrangement/amplification | Rearrangement | 3 copies | Double hit |
DOHH2 | Rearrangement/amplification | Rearrangement | Normal | Double hit |
VAL | Rearrangement | Rearrangement | Rearrangement | Triple hit |
OCILY3 | 3–4 copies | Rearrangement | Rearrangement | BCL2/BCL6 translocation |
OCILY19 | 3–4 copies | Rearrangement | Rearrangement | BCL2/BCL6 translocation |