Skip to main content

Table 1 Identification of MYC, BCL-2, and BCL-6 rearrangements in human DLBCL and BL cell lines: c-MYC, BCL-2, and BCL-6 rearrangements were analyzed with break-apart FISH in human DLBCL (n = 9) and Burkitt Lymphoma cell lines (n = 2)

From: Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

DLBCL cell lines cMYC BCL-2 BCL-6 Status
U2932 Wild-type Amplification 3–4 copies WT-MYC
HBL-1 Wild-type 3 copies Normal WT-MYC
Raji (BL) Rearrangement 3 copies Normal Single hit
Ramos (BL) Rearrangement 1 copy 3 copies Single hit
SUDHL2 Rearrangement/amplification Rearrangement 3 copies Double hit
OCILY1 Rearrangement/amplification Rearrangement 3 copies Double hit
OCILY10 Rearrangement/amplification Rearrangement 3 copies Double hit
DOHH2 Rearrangement/amplification Rearrangement Normal Double hit
VAL Rearrangement Rearrangement Rearrangement Triple hit
OCILY3 3–4 copies Rearrangement Rearrangement BCL2/BCL6 translocation
OCILY19 3–4 copies Rearrangement Rearrangement BCL2/BCL6 translocation